Assay Detail
Functional
CHEMBL863433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against LS174T human colon cell line after 1 hour of exposure
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LS174T |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.44 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219864 | — | — | 1 | 8.22 |
| CHEMBL279754 | DSB-120 | — | 1 | 7.89 |
| CHEMBL374490 | — | — | 1 | 6.70 |
| CHEMBL282988 | — | — | 1 | 4.85 |
| CHEMBL199952 | — | — | 1 | 4.55 |
| CHEMBL382927 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219864 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL279754 | DSB-120 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL374490 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL282988 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL199952 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL382927 | — | IC50 | > | 100000.0 | nM | - |