Assay Detail
Functional
CHEMBL863434
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Cytotoxicity against LS174T human colon cell line after continuous exposure
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LS174T |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.08 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279754 | DSB-120 | — | 1 | 9.33 |
| CHEMBL219864 | — | — | 1 | 9.10 |
| CHEMBL374490 | — | — | 1 | 7.68 |
| CHEMBL282988 | — | — | 1 | 5.85 |
| CHEMBL199952 | — | — | 1 | 5.80 |
| CHEMBL382927 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279754 | DSB-120 | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL219864 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL374490 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL282988 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL199952 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL382927 | — | IC50 | = | 20000.0 | nM | 4.70 |