Assay Detail
Binding
CHEMBL863437
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Inhibitory activity against recombinant human DHODH
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.54 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199361 | — | — | 1 | 9.00 |
| CHEMBL200699 | — | — | 1 | 8.52 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 8.10 |
| CHEMBL345701 | — | — | 1 | 8.10 |
| CHEMBL200856 | — | — | 1 | 8.05 |
| CHEMBL199347 | — | — | 1 | 8.00 |
| CHEMBL383165 | — | — | 1 | 8.00 |
| CHEMBL200858 | — | — | 1 | 7.92 |
| CHEMBL200895 | — | — | 1 | 7.80 |
| CHEMBL371732 | — | — | 1 | 7.36 |
| CHEMBL197194 | VIDOFLUDIMUS | 3.0 | 1 | 6.87 |
| CHEMBL381043 | — | — | 1 | 6.52 |
| CHEMBL370228 | — | — | 1 | 6.47 |
| CHEMBL348270 | — | — | 1 | 6.39 |
| CHEMBL199501 | — | — | 1 | 6.00 |
| CHEMBL371482 | — | — | 1 | - |
| CHEMBL426299 | — | — | 1 | - |
| CHEMBL200894 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199361 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL200699 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL38434 | BREQUINAR | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL345701 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL200856 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL199347 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL383165 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL200858 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL200895 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL371732 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL197194 | VIDOFLUDIMUS | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL381043 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL370228 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL348270 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL199501 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL371482 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL426299 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL200894 | — | IC50 | > | 1000.0 | nM | - |