Assay Detail
Binding
CHEMBL863452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from NET
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.60 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3085032 | — | — | 1 | 6.59 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | 6.07 |
| CHEMBL3085027 | — | — | 1 | 6.00 |
| CHEMBL3085030 | — | — | 1 | 5.79 |
| CHEMBL3350391 | — | — | 1 | 5.74 |
| CHEMBL3085031 | — | — | 1 | 5.61 |
| CHEMBL3085029 | — | — | 1 | 5.54 |
| CHEMBL3085025 | — | — | 1 | 5.50 |
| CHEMBL3085023 | — | — | 1 | 5.45 |
| CHEMBL3085028 | — | — | 1 | 5.25 |
| CHEMBL3085024 | — | — | 1 | 5.12 |
| CHEMBL3085018 | — | — | 1 | 5.08 |
| CHEMBL3085033 | — | — | 1 | 5.08 |
| CHEMBL3085019 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3085032 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | Ki | = | 844.0 | nM | 6.07 |
| CHEMBL3085027 | — | Ki | = | 997.0 | nM | 6.00 |
| CHEMBL3085030 | — | Ki | = | 1630.0 | nM | 5.79 |
| CHEMBL3350391 | — | Ki | = | 1810.0 | nM | 5.74 |
| CHEMBL3085031 | — | Ki | = | 2470.0 | nM | 5.61 |
| CHEMBL3085029 | — | Ki | = | 2920.0 | nM | 5.54 |
| CHEMBL3085025 | — | Ki | = | 3170.0 | nM | 5.50 |
| CHEMBL3085023 | — | Ki | = | 3550.0 | nM | 5.45 |
| CHEMBL3085028 | — | Ki | = | 5580.0 | nM | 5.25 |
| CHEMBL3085024 | — | Ki | = | 7580.0 | nM | 5.12 |
| CHEMBL3085018 | — | Ki | = | 8250.0 | nM | 5.08 |
| CHEMBL3085033 | — | Ki | = | 8410.0 | nM | 5.08 |
| CHEMBL3085019 | — | Ki | = | 152000.0 | nM | - |