Assay Detail
Functional
CHEMBL863565
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Cytotoxicity in human MCF7 cells by SRB assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.06 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201697 | — | — | 1 | 5.06 |
| CHEMBL201766 | — | — | 1 | - |
| CHEMBL383282 | — | — | 1 | - |
| CHEMBL202717 | — | — | 1 | - |
| CHEMBL203366 | — | — | 1 | - |
| CHEMBL202769 | — | — | 1 | - |
| CHEMBL264477 | — | — | 1 | - |
| CHEMBL202562 | — | — | 1 | - |
| CHEMBL202167 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201697 | — | IC50 | = | 8750.0 | nM | 5.06 |
| CHEMBL201766 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL383282 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL202717 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL203366 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL202769 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL264477 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL202562 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL202167 | — | IC50 | > | 25000.0 | nM | - |