Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL863623

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]Cl-DPDPE from human recombinant DOR expressed in CHO cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones.
Nieland NP, Moynihan HA, Carrington S, Broadbear J, Woods JH, Traynor JR, Husbands SM, Lewis JW.
J Med Chem (2006) 49 : 5333 -5338
PubMed 16913723 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 8.82 10.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2113666 1 10.10
CHEMBL607125 1 9.96
CHEMBL607017 1 9.38
CHEMBL607068 1 9.27
CHEMBL607016 1 9.24
CHEMBL607069 1 9.00
CHEMBL610883 1 8.90
CHEMBL607126 1 8.90
CHEMBL611402 1 8.89
CHEMBL386492 CLOCINNAMOX 1 8.57
CHEMBL607127 1 8.54
CHEMBL607018 1 8.40
CHEMBL386272 1 8.32
CHEMBL19019 NALTREXONE 4.0 1 7.97
CHEMBL70 MORPHINE 4.0 1 6.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2113666 Ki = 0.08 nM 10.10
CHEMBL607125 Ki = 0.11 nM 9.96
CHEMBL607017 Ki = 0.42 nM 9.38
CHEMBL607068 Ki = 0.54 nM 9.27
CHEMBL607016 Ki = 0.58 nM 9.24
CHEMBL607069 Ki = 1.0 nM 9.00
CHEMBL610883 Ki = 1.25 nM 8.90
CHEMBL607126 Ki = 1.25 nM 8.90
CHEMBL611402 Ki = 1.3 nM 8.89
CHEMBL386492 CLOCINNAMOX Ki = 2.7 nM 8.57
CHEMBL607127 Ki = 2.9 nM 8.54
CHEMBL607018 Ki = 4.0 nM 8.40
CHEMBL386272 Ki = 4.8 nM 8.32
CHEMBL19019 NALTREXONE Ki = 10.8 nM 7.97
CHEMBL70 MORPHINE Ki = 140.0 nM 6.85