Assay Detail
Functional
CHEMBL863710
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Effect on collagen accumulation in osteoclast bone resorption assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Osteoclast |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.58 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203665 | RELACATIB | 2.0 | 1 | 7.70 |
| CHEMBL205172 | — | — | 1 | 7.70 |
| CHEMBL202668 | — | — | 1 | 7.70 |
| CHEMBL286364 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203665 | RELACATIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL205172 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL202668 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL286364 | — | IC50 | = | 63.0 | nM | 7.20 |