Assay Detail
Binding
CHEMBL863728
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Inhibition of caspase2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.14 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438969 | — | — | 1 | 6.64 |
| CHEMBL439872 | — | — | 1 | 6.63 |
| CHEMBL382481 | — | — | 1 | 6.28 |
| CHEMBL203709 | — | — | 1 | 6.27 |
| CHEMBL202971 | — | — | 1 | 6.07 |
| CHEMBL206435 | — | — | 1 | 5.82 |
| CHEMBL204245 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438969 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL439872 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL382481 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL203709 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL202971 | — | IC50 | = | 859.0 | nM | 6.07 |
| CHEMBL206435 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL204245 | — | IC50 | = | 5670.0 | nM | 5.25 |