Assay Detail
Binding
CHEMBL863793
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cathepsin B from human brain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel series of urea-based peptidomimetic calpain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.94 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206243 | — | — | 1 | 7.70 |
| CHEMBL378702 | — | — | 1 | 6.92 |
| CHEMBL378731 | — | — | 1 | 4.66 |
| CHEMBL205436 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206243 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL378702 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL378731 | — | Ki | = | 22100.0 | nM | 4.66 |
| CHEMBL205436 | — | Ki | = | 33300.0 | nM | 4.48 |