Assay Detail
Binding
CHEMBL863829
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Inhibition of human isolated cPLA2-alpha by vesicle assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.21 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443834 | — | — | 1 | 8.37 |
| CHEMBL426665 | — | — | 1 | 8.31 |
| CHEMBL30108 | — | — | 1 | 7.96 |
| CHEMBL381294 | — | — | 1 | 7.82 |
| CHEMBL207977 | — | — | 1 | 7.80 |
| CHEMBL204618 | — | — | 1 | 7.80 |
| CHEMBL208401 | — | — | 1 | 7.70 |
| CHEMBL205892 | — | — | 1 | 7.46 |
| CHEMBL205753 | — | — | 1 | 6.96 |
| CHEMBL204302 | — | — | 1 | 6.92 |
| CHEMBL206943 | — | — | 1 | 6.47 |
| CHEMBL425596 | — | — | 1 | 6.05 |
| CHEMBL205941 | — | — | 1 | 5.96 |
| CHEMBL409321 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443834 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL426665 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL30108 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL381294 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL207977 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL204618 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL208401 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL205892 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL205753 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL204302 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL206943 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL425596 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL205941 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL409321 | — | IC50 | = | 4300.0 | nM | 5.37 |