Assay Detail
Functional
CHEMBL863833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.78 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443834 | — | — | 1 | 9.05 |
| CHEMBL426665 | — | — | 1 | 8.96 |
| CHEMBL207977 | — | — | 1 | 8.19 |
| CHEMBL208401 | — | — | 1 | 8.11 |
| CHEMBL204618 | — | — | 1 | 8.01 |
| CHEMBL381294 | — | — | 1 | 7.96 |
| CHEMBL205892 | — | — | 1 | 7.75 |
| CHEMBL205753 | — | — | 1 | 6.92 |
| CHEMBL206943 | — | — | 1 | 6.64 |
| CHEMBL425596 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443834 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL426665 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL207977 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL208401 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL204618 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL381294 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL205892 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL205753 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL206943 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL425596 | — | IC50 | = | 560.0 | nM | 6.25 |