Assay Detail
Binding
CHEMBL863916
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Binding affinity to Plasmodium falciparum DHODH
12
Total Activities
6
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Dihydroorotate dehydrogenase (CHEMBL3486) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.20 | 4.37 |
| Ki | 4 | 4.96 | 5.31 |
| Ki app | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199572 | — | — | 2 | 5.31 |
| CHEMBL372561 | — | — | 2 | 4.97 |
| CHEMBL199574 | — | — | 2 | 4.79 |
| CHEMBL370865 | — | — | 2 | 4.75 |
| CHEMBL199575 | — | — | 2 | - |
| CHEMBL200536 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199572 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL372561 | — | Ki | = | 10800.0 | nM | 4.97 |
| CHEMBL199574 | — | Ki | = | 16400.0 | nM | 4.79 |
| CHEMBL370865 | — | Ki | = | 17700.0 | nM | 4.75 |
| CHEMBL199572 | — | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL372561 | — | IC50 | = | 93400.0 | nM | 4.03 |
| CHEMBL199574 | — | IC50 | = | 142600.0 | nM | - |
| CHEMBL370865 | — | IC50 | = | 153500.0 | nM | - |
| CHEMBL199575 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL199575 | — | Ki app | - | — | - | |
| CHEMBL200536 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL200536 | — | Ki app | - | — | - |