Assay Detail
Binding
CHEMBL863918
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human DHODH
12
Total Activities
6
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.08 | 5.30 |
| Ki app | 3 | - | - |
| Ki | 3 | 5.96 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370865 | — | — | 2 | 6.16 |
| CHEMBL199574 | — | — | 2 | 5.96 |
| CHEMBL200536 | — | — | 2 | 5.75 |
| CHEMBL199572 | — | — | 2 | - |
| CHEMBL199575 | — | — | 2 | - |
| CHEMBL372561 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370865 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL199574 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL200536 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL370865 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL199574 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL200536 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL199572 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL199572 | — | Ki app | - | — | - | |
| CHEMBL199575 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL199575 | — | Ki app | - | — | - | |
| CHEMBL372561 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL372561 | — | Ki app | - | — | - |