Assay Detail
Binding
CHEMBL863930
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Inhibitory activity against ACAT in rat macrophages
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.17 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557982 | — | — | 1 | 8.27 |
| CHEMBL541893 | — | — | 1 | 8.08 |
| CHEMBL382183 | — | — | 1 | 7.96 |
| CHEMBL556797 | — | — | 1 | 7.85 |
| CHEMBL539597 | — | — | 1 | 7.68 |
| CHEMBL538824 | — | — | 1 | 7.37 |
| CHEMBL539337 | — | — | 1 | 7.21 |
| CHEMBL558774 | — | — | 1 | 6.42 |
| CHEMBL537859 | — | — | 1 | 6.37 |
| CHEMBL538571 | — | — | 1 | 6.34 |
| CHEMBL540370 | — | — | 1 | 6.27 |
| CHEMBL537863 | — | — | 1 | 6.17 |
| CHEMBL538826 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557982 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL541893 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL382183 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL556797 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL539597 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL538824 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL539337 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL558774 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL537859 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL538571 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL540370 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL537863 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL538826 | — | IC50 | > | 1000.0 | nM | - |