Assay Detail
Binding
CHEMBL863939
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Inhibitory activity against human ERK2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.78 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199395 | — | — | 1 | 6.25 |
| CHEMBL370379 | — | — | 1 | 5.85 |
| CHEMBL259551 | — | — | 1 | 5.72 |
| CHEMBL369976 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199395 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL370379 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL259551 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL369976 | — | IC50 | = | 5100.0 | nM | 5.29 |