Assay Detail
Binding
CHEMBL864093
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Inhibition of COX2 in human whole blood
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Racemic and chiral sulfoxides as potential prodrugs of 4-pyrone COX-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.30 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127211 | — | — | 1 | 7.10 |
| CHEMBL125460 | — | — | 1 | 6.82 |
| CHEMBL209408 | — | — | 1 | 6.70 |
| CHEMBL442767 | — | — | 1 | 6.70 |
| CHEMBL208704 | — | — | 1 | 6.60 |
| CHEMBL2096836 | — | — | 1 | 6.57 |
| CHEMBL212463 | — | — | 1 | 6.24 |
| CHEMBL210897 | — | — | 1 | 6.17 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 6.12 |
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | 6.09 |
| CHEMBL209883 | — | — | 1 | 6.04 |
| CHEMBL2096835 | — | — | 1 | 5.80 |
| CHEMBL212527 | — | — | 1 | 5.68 |
| CHEMBL2096834 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127211 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL125460 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL209408 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL442767 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL208704 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2096836 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL212463 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL210897 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL416146 | ETORICOXIB | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL209883 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2096835 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL212527 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2096834 | — | IC50 | = | 2470.0 | nM | 5.61 |