Assay Detail
Functional
CHEMBL864185
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Cytotoxicity against human SK-Br-3 cell line by clonogenic plating efficiency assay after 72 hrs
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Semisynthetic maytansine analogues for the targeted treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 9.55 | 10.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378080 | — | — | 1 | 10.85 |
| CHEMBL209438 | — | — | 1 | 10.57 |
| CHEMBL292702 | MAYTANSINE | 2.0 | 1 | 10.52 |
| CHEMBL380013 | — | — | 1 | 10.51 |
| CHEMBL209578 | — | — | 1 | 10.49 |
| CHEMBL379039 | — | — | 1 | 10.42 |
| CHEMBL413839 | — | — | 1 | 10.00 |
| CHEMBL411544 | — | — | 1 | 9.92 |
| CHEMBL210809 | — | — | 1 | 9.66 |
| CHEMBL407943 | — | — | 1 | 8.96 |
| CHEMBL214154 | MAYTANSINOL | — | 1 | 8.92 |
| CHEMBL437686 | — | — | 1 | 8.66 |
| CHEMBL376972 | — | — | 1 | 8.48 |
| CHEMBL379534 | — | — | 1 | 8.47 |
| CHEMBL377395 | — | — | 1 | 8.22 |
| CHEMBL264834 | — | — | 1 | 8.15 |
| CHEMBL385822 | — | — | 1 | - |
| CHEMBL211840 | — | — | 1 | - |
| CHEMBL376935 | — | — | 1 | - |
| CHEMBL211886 | — | — | 1 | - |
| CHEMBL373986 | — | — | 1 | - |
| CHEMBL210041 | — | — | 1 | - |
| CHEMBL378079 | METHYLDITHIOACETYL MAYTANSINOID | — | 1 | - |
| CHEMBL448167 | — | — | 1 | - |
| CHEMBL376971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378080 | — | IC50 | = | 0.014 | nM | 10.85 |
| CHEMBL209438 | — | IC50 | = | 0.027 | nM | 10.57 |
| CHEMBL292702 | MAYTANSINE | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL380013 | — | IC50 | = | 0.031 | nM | 10.51 |
| CHEMBL209578 | — | IC50 | = | 0.032 | nM | 10.49 |
| CHEMBL379039 | — | IC50 | = | 0.038 | nM | 10.42 |
| CHEMBL413839 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL411544 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL210809 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL407943 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL214154 | MAYTANSINOL | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL437686 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL376972 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL379534 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL377395 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL264834 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL385822 | — | IC50 | = | 0.0032 | nM | - |
| CHEMBL211840 | — | IC50 | = | 0.0042 | nM | - |
| CHEMBL376935 | — | IC50 | - | — | - | |
| CHEMBL211886 | — | IC50 | - | — | - | |
| CHEMBL373986 | — | IC50 | > | 3.0 | nM | - |
| CHEMBL210041 | — | IC50 | > | 0.3 | nM | - |
| CHEMBL378079 | METHYLDITHIOACETYL MAYTANSINOID | IC50 | - | — | - | |
| CHEMBL448167 | — | IC50 | = | 0.0012 | nM | - |
| CHEMBL376971 | — | IC50 | > | 3.0 | nM | - |