Assay Detail

CHEMBL864187

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Functional

Cytotoxicity against human A549 cell line by clonogenic plating efficiency assay after 72 hrs

ChEMBL ↗

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Target

A549 (CHEMBL392) ↗

Open DB target context

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A549 (CHEMBL392) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target A549

CHEMBL392

Anchored from Assay target.

Protein identity A549

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	A549
Confidence	1 — Organism
Curated By	Intermediate

Target

A549 (CHEMBL392) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Semisynthetic maytansine analogues for the targeted treatment of cancer.

Widdison WC, Wilhelm SD, Cavanagh EE, Whiteman KR, Leece BA, Kovtun Y, Goldmacher VS, Xie H, Steeves RM, Lutz RJ, Zhao R, Wang L, Blättler WA, Chari RV.
J Med Chem (2006) 49 : 4392 -4408
PubMed 16821799 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	9.86	9.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL378080	—	—	1	9.92
CHEMBL292702	MAYTANSINE	2.0	1	9.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL378080	—	IC50	=	0.12	nM	9.92
CHEMBL292702	MAYTANSINE	IC50	=	0.16	nM	9.80