Assay Detail
Binding
CHEMBL864199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human trypsin
35
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.40 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214149 | — | — | 1 | 8.43 |
| CHEMBL214367 | — | — | 1 | 7.96 |
| CHEMBL209604 | — | — | 1 | 7.96 |
| CHEMBL378244 | — | — | 1 | 7.92 |
| CHEMBL213951 | — | — | 1 | 7.89 |
| CHEMBL214148 | — | — | 1 | 7.85 |
| CHEMBL211638 | — | — | 1 | 7.82 |
| CHEMBL188069 | — | — | 1 | 7.75 |
| CHEMBL276908 | — | — | 1 | 7.75 |
| CHEMBL379561 | — | — | 1 | 7.72 |
| CHEMBL213780 | — | — | 1 | 7.70 |
| CHEMBL213927 | — | — | 2 | 7.68 |
| CHEMBL213698 | — | — | 1 | 7.66 |
| CHEMBL213778 | — | — | 1 | 7.66 |
| CHEMBL377890 | — | — | 1 | 7.64 |
| CHEMBL386704 | — | — | 1 | 7.64 |
| CHEMBL213779 | — | — | 1 | 7.58 |
| CHEMBL414865 | — | — | 1 | 7.57 |
| CHEMBL210129 | — | — | 1 | 7.54 |
| CHEMBL377619 | — | — | 1 | 7.52 |
| CHEMBL379486 | — | — | 1 | 7.51 |
| CHEMBL213554 | — | — | 1 | 7.48 |
| CHEMBL211585 | — | — | 1 | 7.47 |
| CHEMBL426330 | — | — | 1 | 7.46 |
| CHEMBL378910 | — | — | 1 | 7.38 |
| CHEMBL214368 | — | — | 1 | 6.77 |
| CHEMBL209395 | — | — | 1 | 6.75 |
| CHEMBL213928 | — | — | 1 | 6.62 |
| CHEMBL212774 | — | — | 1 | 6.55 |
| CHEMBL377656 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214149 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL209604 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL214367 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL378244 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL213951 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL214148 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL211638 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL188069 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL276908 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL379561 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL213780 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL213927 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL213927 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL213698 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL213778 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL377890 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL386704 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL213779 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL414865 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL210129 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL377619 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL379486 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL213554 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL211585 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL426330 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL378910 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL214368 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL209395 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL213928 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL212774 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL377656 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL379528 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL211357 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL380293 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL214136 | — | Ki | = | 470.0 | nM | 6.33 |