Assay Detail
Functional
CHEMBL864249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDR by cellular assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.64 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196363 | — | — | 1 | 9.00 |
| CHEMBL376951 | — | — | 1 | 9.00 |
| CHEMBL213504 | — | — | 1 | 8.30 |
| CHEMBL445570 | — | — | 1 | 8.30 |
| CHEMBL262433 | — | — | 1 | 7.68 |
| CHEMBL379372 | — | — | 1 | 7.30 |
| CHEMBL211378 | — | — | 1 | 7.00 |
| CHEMBL213505 | — | — | 1 | 6.77 |
| CHEMBL210003 | — | — | 1 | 6.60 |
| CHEMBL378687 | — | — | 1 | 6.42 |
| CHEMBL214258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196363 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL376951 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL213504 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL445570 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL262433 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL379372 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL211378 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL213505 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL210003 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL378687 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL214258 | — | IC50 | - | — | - |