Assay Detail
Binding
CHEMBL864251
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.67 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196363 | — | — | 1 | 8.70 |
| CHEMBL262433 | — | — | 1 | 8.00 |
| CHEMBL213504 | — | — | 1 | 7.41 |
| CHEMBL214258 | — | — | 1 | 7.12 |
| CHEMBL376951 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196363 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL262433 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL213504 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL214258 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL376951 | — | IC50 | = | 79.0 | nM | 7.10 |