Assay Detail
Functional
CHEMBL864285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPR
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.59 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214640 | — | — | 1 | 7.82 |
| CHEMBL66654 | — | — | 1 | 7.66 |
| CHEMBL215941 | — | — | 1 | 7.44 |
| CHEMBL292065 | — | — | 1 | 7.11 |
| CHEMBL215957 | — | — | 1 | 7.08 |
| CHEMBL378219 | — | — | 1 | 7.00 |
| CHEMBL212129 | — | — | 1 | 6.99 |
| CHEMBL212130 | — | — | 1 | 6.94 |
| CHEMBL1161889 | — | — | 1 | 6.52 |
| CHEMBL213102 | — | — | 1 | 6.40 |
| CHEMBL215282 | — | — | 1 | 6.38 |
| CHEMBL215861 | — | — | 1 | 6.34 |
| CHEMBL215561 | — | — | 1 | 6.08 |
| CHEMBL215702 | — | — | 1 | 5.83 |
| CHEMBL212018 | — | — | 1 | 5.81 |
| CHEMBL215120 | — | — | 1 | 5.60 |
| CHEMBL384991 | — | — | 1 | 5.10 |
| CHEMBL215300 | — | — | 1 | - |
| CHEMBL213220 | — | — | 1 | - |
| CHEMBL215058 | — | — | 1 | - |
| CHEMBL215149 | — | — | 1 | - |
| CHEMBL215098 | — | — | 1 | - |
| CHEMBL215097 | — | — | 1 | - |
| CHEMBL214094 | — | — | 1 | - |
| CHEMBL213985 | — | — | 1 | - |
| CHEMBL214538 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214640 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL66654 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL215941 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL292065 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL215957 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL378219 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL212129 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL212130 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL1161889 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL213102 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL215282 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL215861 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL215561 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL215702 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL212018 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL215120 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL384991 | — | IC50 | = | 7926.0 | nM | 5.10 |
| CHEMBL215300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL213220 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL215058 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL215149 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL215098 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL215097 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL214094 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL213985 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL214538 | — | IC50 | > | 10000.0 | nM | - |