Assay Detail
Binding
CHEMBL864301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]I-AB-MECA from human Adenosine A3 receptor expressed in CHO cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.28 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436485 | — | — | 1 | 7.81 |
| CHEMBL373065 | — | — | 1 | 7.54 |
| CHEMBL425581 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436485 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL373065 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL425581 | — | Ki | = | 315.0 | nM | 6.50 |