Assay Detail
Binding
CHEMBL864414
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Inhibition of PKA at 10 uM ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.18 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL383264 | — | — | 1 | 8.68 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.44 |
| CHEMBL383541 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL383264 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL383541 | — | IC50 | = | 38.0 | nM | 7.42 |