Assay Detail
Binding
CHEMBL864419
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Inhibition of Cathepsin B
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of a potent and selective non-basic cathepsin K inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.55 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377285 | — | — | 1 | 6.32 |
| CHEMBL195454 | — | — | 1 | 5.95 |
| CHEMBL381621 | — | — | 1 | 5.94 |
| CHEMBL208278 | — | — | 1 | 5.87 |
| CHEMBL437694 | — | — | 1 | 5.85 |
| CHEMBL207554 | — | — | 1 | 5.81 |
| CHEMBL204792 | — | — | 1 | 5.79 |
| CHEMBL203944 | — | — | 1 | 5.78 |
| CHEMBL382820 | — | — | 1 | 5.73 |
| CHEMBL206024 | — | — | 1 | 5.62 |
| CHEMBL207769 | — | — | 1 | 5.61 |
| CHEMBL204277 | — | — | 1 | 5.52 |
| CHEMBL382038 | — | — | 1 | 5.39 |
| CHEMBL207891 | — | — | 1 | 5.33 |
| CHEMBL381758 | — | — | 1 | 5.32 |
| CHEMBL437501 | — | — | 1 | 5.28 |
| CHEMBL378583 | — | — | 1 | 5.23 |
| CHEMBL205929 | — | — | 1 | 5.23 |
| CHEMBL382576 | — | — | 1 | 5.22 |
| CHEMBL206912 | — | — | 1 | 5.16 |
| CHEMBL380425 | — | — | 1 | 5.13 |
| CHEMBL205504 | — | — | 1 | 5.05 |
| CHEMBL206166 | — | — | 1 | - |
| CHEMBL206169 | — | — | 1 | - |
| CHEMBL204276 | — | — | 1 | - |
| CHEMBL208481 | — | — | 1 | - |
| CHEMBL426493 | — | — | 1 | - |
| CHEMBL206913 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377285 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL195454 | — | IC50 | = | 1111.0 | nM | 5.95 |
| CHEMBL381621 | — | IC50 | = | 1155.0 | nM | 5.94 |
| CHEMBL208278 | — | IC50 | = | 1337.0 | nM | 5.87 |
| CHEMBL437694 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL207554 | — | IC50 | = | 1561.0 | nM | 5.81 |
| CHEMBL204792 | — | IC50 | = | 1605.0 | nM | 5.79 |
| CHEMBL203944 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL382820 | — | IC50 | = | 1873.0 | nM | 5.73 |
| CHEMBL206024 | — | IC50 | = | 2374.0 | nM | 5.62 |
| CHEMBL207769 | — | IC50 | = | 2476.0 | nM | 5.61 |
| CHEMBL204277 | — | IC50 | = | 2993.0 | nM | 5.52 |
| CHEMBL382038 | — | IC50 | = | 4073.0 | nM | 5.39 |
| CHEMBL207891 | — | IC50 | = | 4699.0 | nM | 5.33 |
| CHEMBL381758 | — | IC50 | = | 4818.0 | nM | 5.32 |
| CHEMBL437501 | — | IC50 | = | 5239.0 | nM | 5.28 |
| CHEMBL378583 | — | IC50 | = | 5903.0 | nM | 5.23 |
| CHEMBL205929 | — | IC50 | = | 5939.0 | nM | 5.23 |
| CHEMBL382576 | — | IC50 | = | 6086.0 | nM | 5.22 |
| CHEMBL206912 | — | IC50 | = | 6984.0 | nM | 5.16 |
| CHEMBL380425 | — | IC50 | = | 7392.0 | nM | 5.13 |
| CHEMBL205504 | — | IC50 | = | 8869.0 | nM | 5.05 |
| CHEMBL206166 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL206169 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL204276 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL208481 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL426493 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL206913 | — | IC50 | > | 10000.0 | nM | - |