Assay Detail
Functional
CHEMBL864425
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Activity in rabbit osteoclasts by bone resorption assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Cell Type | Osteoclast |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of a potent and selective non-basic cathepsin K inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.37 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382820 | — | — | 1 | 8.30 |
| CHEMBL195454 | — | — | 1 | 7.92 |
| CHEMBL437501 | — | — | 1 | 7.89 |
| CHEMBL377285 | — | — | 1 | 7.85 |
| CHEMBL206024 | — | — | 1 | 7.72 |
| CHEMBL208278 | — | — | 1 | 7.57 |
| CHEMBL382576 | — | — | 1 | 7.55 |
| CHEMBL205929 | — | — | 1 | 7.54 |
| CHEMBL380425 | — | — | 1 | 7.52 |
| CHEMBL381621 | — | — | 1 | 7.48 |
| CHEMBL204792 | — | — | 1 | 7.36 |
| CHEMBL205504 | — | — | 1 | 7.34 |
| CHEMBL437694 | — | — | 1 | 7.30 |
| CHEMBL206912 | — | — | 1 | 7.28 |
| CHEMBL381758 | — | — | 1 | 7.28 |
| CHEMBL207554 | — | — | 1 | 7.28 |
| CHEMBL207769 | — | — | 1 | 7.17 |
| CHEMBL207891 | — | — | 1 | 7.10 |
| CHEMBL206913 | — | — | 1 | 7.06 |
| CHEMBL378583 | — | — | 1 | 7.03 |
| CHEMBL204277 | — | — | 1 | 6.96 |
| CHEMBL382038 | — | — | 1 | 6.93 |
| CHEMBL426493 | — | — | 1 | 6.82 |
| CHEMBL204276 | — | — | 1 | 6.70 |
| CHEMBL203944 | — | — | 1 | - |
| CHEMBL208481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382820 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL195454 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL437501 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL377285 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL206024 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL208278 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL382576 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL205929 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL380425 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL381621 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL204792 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL205504 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL437694 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL206912 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL381758 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL207554 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL207769 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL207891 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL206913 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL378583 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL204277 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL382038 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL426493 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL204276 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL203944 | — | IC50 | - | — | - | |
| CHEMBL208481 | — | IC50 | - | — | - |