Assay Detail
Functional
CHEMBL864468
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Transcriptional activity against RARbeta2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.61 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.20 |
| CHEMBL198997 | — | — | 1 | 8.00 |
| CHEMBL197292 | — | — | 1 | 7.80 |
| CHEMBL198794 | — | — | 1 | 7.80 |
| CHEMBL69367 | — | — | 1 | 7.70 |
| CHEMBL371684 | — | — | 1 | 7.60 |
| CHEMBL198467 | — | — | 1 | 7.30 |
| CHEMBL365798 | — | — | 1 | 7.20 |
| CHEMBL425027 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL198997 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL197292 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL198794 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL69367 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL371684 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL198467 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL365798 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL425027 | — | EC50 | = | 125.89 | nM | 6.90 |