Assay Detail
Binding
CHEMBL864475
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CFT from human DAT expressed in COS7 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.08 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42553 | — | — | 1 | 9.70 |
| CHEMBL196760 | — | — | 1 | 7.75 |
| CHEMBL372378 | — | — | 1 | 7.57 |
| CHEMBL198842 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42553 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL196760 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL372378 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL198842 | — | Ki | = | 50.0 | nM | 7.30 |