Assay Detail
Binding
CHEMBL864478
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Mixed inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrate
20
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.20 | 6.82 |
| Ki' | 7 | - | - |
| IC50 | 5 | 4.42 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199020 | — | — | 1 | 6.82 |
| CHEMBL197230 | — | — | 2 | 6.36 |
| CHEMBL371088 | — | — | 3 | 4.95 |
| CHEMBL372379 | — | — | 3 | 4.70 |
| CHEMBL198590 | — | — | 3 | 4.61 |
| CHEMBL197131 | — | — | 3 | 4.61 |
| CHEMBL370195 | — | — | 3 | 4.37 |
| CHEMBL197537 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199020 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL197230 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL371088 | — | Ki | = | 11300.0 | nM | 4.95 |
| CHEMBL372379 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL198590 | — | Ki | = | 24500.0 | nM | 4.61 |
| CHEMBL197131 | — | Ki | = | 24600.0 | nM | 4.61 |
| CHEMBL371088 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL372379 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL197131 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL370195 | — | Ki | = | 42800.0 | nM | 4.37 |
| CHEMBL370195 | — | IC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL198590 | — | IC50 | = | 49600.0 | nM | 4.30 |
| CHEMBL197230 | — | Ki' | = | 3.5 | uM | - |
| CHEMBL197537 | — | Ki' | = | 0.86 | mM | - |
| CHEMBL197537 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL370195 | — | Ki' | = | 12.9 | uM | - |
| CHEMBL198590 | — | Ki' | = | 37.7 | uM | - |
| CHEMBL372379 | — | Ki' | = | 29.3 | uM | - |
| CHEMBL371088 | — | Ki' | = | 42.6 | uM | - |
| CHEMBL197131 | — | Ki' | = | 35.9 | uM | - |