Assay Detail
Functional
CHEMBL864486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against VEGF-stimulated proliferation in HUVEC
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor (CHEMBL2095227) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.31 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150315 | — | — | 1 | 6.00 |
| CHEMBL199725 | — | — | 1 | 5.72 |
| CHEMBL199573 | — | — | 1 | 5.50 |
| CHEMBL382716 | — | — | 1 | 5.39 |
| CHEMBL200085 | — | — | 1 | 4.83 |
| CHEMBL199460 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150315 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL199725 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL199573 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL382716 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL200085 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL199460 | — | IC50 | = | 40300.0 | nM | 4.39 |