Assay Detail
Binding
CHEMBL864487
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Inhibitory activity against lck
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.45 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371295 | — | — | 1 | 7.64 |
| CHEMBL199438 | — | — | 1 | 7.27 |
| CHEMBL370773 | — | — | 1 | 7.13 |
| CHEMBL200587 | — | — | 1 | 7.10 |
| CHEMBL371459 | — | — | 1 | 7.03 |
| CHEMBL198239 | — | — | 1 | 6.99 |
| CHEMBL381203 | — | — | 1 | 6.97 |
| CHEMBL198136 | — | — | 1 | 6.97 |
| CHEMBL199369 | — | — | 1 | 6.97 |
| CHEMBL197603 | — | — | 1 | 6.83 |
| CHEMBL382939 | — | — | 1 | 6.50 |
| CHEMBL373054 | — | — | 1 | 6.47 |
| CHEMBL200424 | — | — | 1 | 5.63 |
| CHEMBL440213 | — | — | 1 | 5.46 |
| CHEMBL370383 | — | — | 1 | 5.05 |
| CHEMBL199816 | — | — | 1 | 5.04 |
| CHEMBL370670 | — | — | 1 | 4.63 |
| CHEMBL199813 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371295 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL199438 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL370773 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL200587 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL371459 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL198239 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL381203 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL198136 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL199369 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL197603 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL382939 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL373054 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL200424 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL440213 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL370383 | — | IC50 | = | 8960.0 | nM | 5.05 |
| CHEMBL199816 | — | IC50 | = | 9180.0 | nM | 5.04 |
| CHEMBL370670 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL199813 | — | IC50 | > | 50000.0 | nM | - |