Assay Detail
Functional
CHEMBL864523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity at ADRA1A in isolated rat prostatic vas deferens
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pKb | 4 | - | - |
| Kd | 1 | 9.51 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 9.51 |
| CHEMBL370364 | — | — | 1 | - |
| CHEMBL372222 | — | — | 1 | - |
| CHEMBL199876 | — | — | 1 | - |
| CHEMBL370136 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Kd | = | 0.309 | nM | 9.51 |
| CHEMBL370364 | — | pKb | = | 7.25 | — | - |
| CHEMBL372222 | — | pKb | = | 6.72 | — | - |
| CHEMBL199876 | — | pKb | = | 6.41 | — | - |
| CHEMBL370136 | — | pKb | = | 7.48 | — | - |