Assay Detail
Binding
CHEMBL864534
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Inhibitory activity against caspase 7 using Ac-DEVD-AMC substrate
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.31 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197549 | — | — | 1 | 7.85 |
| CHEMBL200653 | — | — | 1 | 7.84 |
| CHEMBL198682 | — | — | 1 | 7.82 |
| CHEMBL372322 | — | — | 1 | 7.82 |
| CHEMBL370012 | — | — | 1 | 7.77 |
| CHEMBL200886 | — | — | 1 | 7.68 |
| CHEMBL200677 | — | — | 1 | 7.66 |
| CHEMBL372994 | — | — | 1 | 7.65 |
| CHEMBL371687 | — | — | 1 | 7.64 |
| CHEMBL372607 | — | — | 1 | 7.64 |
| CHEMBL198755 | — | — | 1 | 7.63 |
| CHEMBL200813 | — | — | 1 | 7.63 |
| CHEMBL200493 | — | — | 1 | 7.58 |
| CHEMBL382084 | — | — | 1 | 7.57 |
| CHEMBL439753 | — | — | 1 | 7.55 |
| CHEMBL200785 | — | — | 1 | 7.53 |
| CHEMBL200476 | — | — | 1 | 7.46 |
| CHEMBL200220 | — | — | 1 | 7.39 |
| CHEMBL200927 | — | — | 1 | 7.36 |
| CHEMBL373012 | — | — | 1 | 7.24 |
| CHEMBL371879 | — | — | 1 | 7.02 |
| CHEMBL196855 | — | — | 1 | 6.87 |
| CHEMBL197237 | — | — | 1 | 6.85 |
| CHEMBL197535 | — | — | 1 | 6.67 |
| CHEMBL293034 | — | — | 1 | 6.51 |
| CHEMBL371709 | — | — | 1 | 6.44 |
| CHEMBL62993 | — | — | 1 | 6.27 |
| CHEMBL200767 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197549 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL200653 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL198682 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL372322 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL370012 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL200886 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL200677 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL372994 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL371687 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL372607 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL198755 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL200813 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL200493 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL382084 | — | IC50 | = | 26.7 | nM | 7.57 |
| CHEMBL439753 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL200785 | — | IC50 | = | 29.5 | nM | 7.53 |
| CHEMBL200476 | — | IC50 | = | 34.8 | nM | 7.46 |
| CHEMBL200220 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL200927 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL373012 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL371879 | — | IC50 | = | 94.9 | nM | 7.02 |
| CHEMBL196855 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL197237 | — | IC50 | = | 142.3 | nM | 6.85 |
| CHEMBL197535 | — | IC50 | = | 214.9 | nM | 6.67 |
| CHEMBL293034 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL371709 | — | IC50 | = | 362.5 | nM | 6.44 |
| CHEMBL62993 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL200767 | — | IC50 | = | 1350.0 | nM | 5.87 |