Assay Detail
Binding
CHEMBL864539
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Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.65 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64605 | — | — | 1 | 7.60 |
| CHEMBL13577 | — | — | 1 | 6.70 |
| CHEMBL370355 | — | — | 1 | 6.28 |
| CHEMBL382952 | — | — | 1 | 6.03 |
| CHEMBL380592 | — | — | 1 | - |
| CHEMBL445662 | — | — | 1 | - |
| CHEMBL200953 | — | — | 1 | - |
| CHEMBL382953 | — | — | 1 | - |
| CHEMBL198902 | — | — | 1 | - |
| CHEMBL436510 | — | — | 1 | - |
| CHEMBL425392 | — | — | 1 | - |
| CHEMBL371019 | — | — | 1 | - |
| CHEMBL200490 | — | — | 1 | - |
| CHEMBL371288 | — | — | 1 | - |
| CHEMBL436123 | — | — | 1 | - |
| CHEMBL276837 | — | — | 1 | - |
| CHEMBL380567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64605 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL13577 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL370355 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL382952 | — | IC50 | = | 938.0 | nM | 6.03 |
| CHEMBL380592 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL445662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL200953 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL382953 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL198902 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL436510 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL425392 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL371019 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL200490 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL371288 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL436123 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL276837 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL380567 | — | IC50 | > | 10000.0 | nM | - |