Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL864542

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of calpain I in C2C12 myoblasts loaded with Suc-Leu-Tyr-AMC
ChEMBL ↗
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Novel cell-penetrating alpha-keto-amide calpain inhibitors as potential treatment for muscular dystrophy.
Lescop C, Herzner H, Siendt H, Bolliger R, Henneböhle M, Weyermann P, Briguet A, Courdier-Fruh I, Erb M, Foster M, Meier T, Magyar JP, von Sprecher A.
Bioorg Med Chem Lett (2005) 15 : 5176 -5181
PubMed 16185867 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 49 5.69 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL200283 — — 1 6.70
CHEMBL200419 — — 1 6.66
CHEMBL200147 — — 1 6.60
CHEMBL201987 — — 1 6.60
CHEMBL372348 — — 1 6.55
CHEMBL371038 — — 1 6.46
CHEMBL198962 — — 1 6.46
CHEMBL199007 — — 1 6.41
CHEMBL198636 — — 1 6.40
CHEMBL198620 — — 1 6.40
CHEMBL369951 — — 1 6.40
CHEMBL200826 — — 1 6.30
CHEMBL200430 — — 1 6.16
CHEMBL195183 — — 1 6.10
CHEMBL381417 — — 1 6.00
CHEMBL200254 — — 1 6.00
CHEMBL200645 — — 1 5.96
CHEMBL199758 — — 1 5.82
CHEMBL200603 — — 1 5.75
CHEMBL197438 — — 1 5.70
CHEMBL370163 — — 1 5.70
CHEMBL200872 — — 1 5.60
CHEMBL197060 — — 1 5.60
CHEMBL200096 — — 1 5.52
CHEMBL200784 — — 1 5.50
CHEMBL198587 — — 1 5.46
CHEMBL198638 — — 1 5.46
CHEMBL197018 — — 1 5.35
CHEMBL200402 — — 1 5.30
CHEMBL200604 — — 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL200283 — IC50 = 200.0 nM 6.70
CHEMBL200419 — IC50 = 220.0 nM 6.66
CHEMBL201987 — IC50 = 250.0 nM 6.60
CHEMBL200147 — IC50 = 250.0 nM 6.60
CHEMBL372348 — IC50 = 280.0 nM 6.55
CHEMBL371038 — IC50 = 350.0 nM 6.46
CHEMBL198962 — IC50 = 350.0 nM 6.46
CHEMBL199007 — IC50 = 390.0 nM 6.41
CHEMBL198636 — IC50 = 400.0 nM 6.40
CHEMBL198620 — IC50 = 400.0 nM 6.40
CHEMBL369951 — IC50 = 400.0 nM 6.40
CHEMBL200826 — IC50 = 500.0 nM 6.30
CHEMBL200430 — IC50 = 700.0 nM 6.16
CHEMBL195183 — IC50 = 800.0 nM 6.10
CHEMBL200254 — IC50 = 1000.0 nM 6.00
CHEMBL381417 — IC50 = 1000.0 nM 6.00
CHEMBL200645 — IC50 = 1100.0 nM 5.96
CHEMBL199758 — IC50 = 1500.0 nM 5.82
CHEMBL200603 — IC50 = 1800.0 nM 5.75
CHEMBL197438 — IC50 = 2000.0 nM 5.70
CHEMBL370163 — IC50 = 2000.0 nM 5.70
CHEMBL200872 — IC50 = 2500.0 nM 5.60
CHEMBL197060 — IC50 = 2500.0 nM 5.60
CHEMBL200096 — IC50 = 3000.0 nM 5.52
CHEMBL200784 — IC50 = 3200.0 nM 5.50
CHEMBL198638 — IC50 = 3500.0 nM 5.46
CHEMBL198587 — IC50 = 3500.0 nM 5.46
CHEMBL197018 — IC50 = 4500.0 nM 5.35
CHEMBL200402 — IC50 = 5000.0 nM 5.30
CHEMBL200604 — IC50 = 5000.0 nM 5.30
CHEMBL198480 — IC50 = 5000.0 nM 5.30
CHEMBL424668 — IC50 = 6000.0 nM 5.22
CHEMBL370597 — IC50 = 6000.0 nM 5.22
CHEMBL371772 — IC50 = 9000.0 nM 5.05
CHEMBL371892 — IC50 = 10000.0 nM 5.00
CHEMBL423112 — IC50 = 10000.0 nM 5.00
CHEMBL371773 — IC50 = 15000.0 nM 4.82
CHEMBL426828 — IC50 = 15000.0 nM 4.82
CHEMBL370553 — IC50 = 20000.0 nM 4.70
CHEMBL199482 — IC50 = 25000.0 nM 4.60
CHEMBL200468 — IC50 = 30000.0 nM 4.52
CHEMBL263829 — IC50 = 40000.0 nM 4.40
CHEMBL373191 — IC50 - — -
CHEMBL200307 — IC50 - — -
CHEMBL370610 — IC50 - — -
CHEMBL197476 — IC50 - — -
CHEMBL198539 — IC50 - — -
CHEMBL435932 — IC50 - — -
CHEMBL200873 — IC50 > 10000.0 nM -