Assay Detail
Functional
CHEMBL864561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding potency at human S1P1 receptor by [35S]GTP-gamma-S binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.40 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382739 | — | — | 1 | 9.10 |
| CHEMBL199791 | — | — | 1 | 9.00 |
| CHEMBL371758 | — | — | 1 | 9.00 |
| CHEMBL203475 | — | — | 1 | 7.70 |
| CHEMBL199754 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382739 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL199791 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL371758 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL203475 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL199754 | — | EC50 | = | 63.1 | nM | 7.20 |