Assay Detail
Functional
CHEMBL864630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [35S]GTP-gamma-S from rat cerebellar CB1 receptor
48
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 5.73 | 8.30 |
| Emax | 24 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307696 | — | — | 2 | 8.30 |
| CHEMBL336670 | — | — | 2 | 8.00 |
| CHEMBL199561 | — | — | 2 | 8.00 |
| CHEMBL559612 | CP-55940 | — | 2 | 7.00 |
| CHEMBL465 | DRONABINOL | 4.0 | 2 | 6.70 |
| CHEMBL74415 | CANNABINOL | 3.0 | 2 | 6.50 |
| CHEMBL151167 | — | — | 2 | 6.50 |
| CHEMBL418353 | — | — | 2 | 6.40 |
| CHEMBL267227 | DELTA-8-TETRAHYDROCANNABINOL | 2.0 | 2 | 6.20 |
| CHEMBL201758 | — | — | 2 | 5.90 |
| CHEMBL371214 | — | — | 2 | 5.70 |
| CHEMBL380923 | — | — | 2 | 5.70 |
| CHEMBL199911 | — | — | 2 | 5.50 |
| CHEMBL201260 | — | — | 2 | 5.50 |
| CHEMBL150849 | — | — | 2 | 5.10 |
| CHEMBL15848 | ANANDAMIDE | — | 2 | 4.80 |
| CHEMBL203474 | — | — | 2 | 4.80 |
| CHEMBL113473 | — | — | 2 | 4.60 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | — | 2 | 4.60 |
| CHEMBL200113 | — | — | 2 | 4.40 |
| CHEMBL320549 | — | — | 2 | 4.40 |
| CHEMBL371953 | — | — | 2 | 4.30 |
| CHEMBL199668 | — | — | 2 | 4.30 |
| CHEMBL381893 | — | — | 2 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307696 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL199561 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL336670 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL559612 | CP-55940 | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL465 | DRONABINOL | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL151167 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL74415 | CANNABINOL | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL418353 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL267227 | DELTA-8-TETRAHYDROCANNABINOL | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL201758 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL380923 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL371214 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL201260 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL199911 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL150849 | — | EC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL15848 | ANANDAMIDE | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL203474 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL113473 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL320549 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL200113 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL381893 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL199668 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL371953 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL199668 | — | Emax | = | 382.0 | % | - |
| CHEMBL465 | DRONABINOL | Emax | = | 159.0 | % | - |
| CHEMBL201260 | — | Emax | = | 199.0 | % | - |
| CHEMBL381893 | — | Emax | = | 474.0 | % | - |
| CHEMBL199911 | — | Emax | = | 213.0 | % | - |
| CHEMBL371214 | — | Emax | = | 158.0 | % | - |
| CHEMBL74415 | CANNABINOL | Emax | = | 131.0 | % | - |
| CHEMBL199561 | — | Emax | = | 400.0 | % | - |
| CHEMBL336670 | — | Emax | = | 369.0 | % | - |
| CHEMBL307696 | — | Emax | = | 396.0 | % | - |
| CHEMBL559612 | CP-55940 | Emax | = | 443.0 | % | - |
| CHEMBL267227 | DELTA-8-TETRAHYDROCANNABINOL | Emax | = | 184.0 | % | - |
| CHEMBL371953 | — | Emax | = | 332.0 | % | - |
| CHEMBL200113 | — | Emax | = | 352.0 | % | - |
| CHEMBL151167 | — | Emax | = | 326.0 | % | - |
| CHEMBL203474 | — | Emax | = | 284.0 | % | - |
| CHEMBL320549 | — | Emax | = | 269.0 | % | - |
| CHEMBL150849 | — | Emax | = | 286.0 | % | - |
| CHEMBL15848 | ANANDAMIDE | Emax | = | 380.0 | % | - |
| CHEMBL113473 | — | Emax | = | 255.0 | % | - |
| CHEMBL380923 | — | Emax | = | 260.0 | % | - |
| CHEMBL201758 | — | Emax | = | 210.0 | % | - |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | Emax | = | 161.0 | % | - |
| CHEMBL418353 | — | Emax | = | 351.0 | % | - |