Assay Detail
Binding
CHEMBL864674
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Inhibitory activity against farnesyltransferase quantified by SPA assay
44
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.72 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381360 | — | — | 3 | 8.82 |
| CHEMBL372343 | — | — | 1 | 8.26 |
| CHEMBL202272 | — | — | 1 | 8.24 |
| CHEMBL378816 | — | — | 1 | 8.15 |
| CHEMBL201844 | — | — | 1 | 8.15 |
| CHEMBL369933 | — | — | 1 | 8.14 |
| CHEMBL371962 | — | — | 1 | 8.14 |
| CHEMBL201043 | — | — | 1 | 8.10 |
| CHEMBL408569 | — | — | 1 | 8.10 |
| CHEMBL201817 | — | — | 1 | 8.10 |
| CHEMBL370411 | — | — | 1 | 8.10 |
| CHEMBL381736 | — | — | 1 | 8.08 |
| CHEMBL372350 | — | — | 1 | 8.04 |
| CHEMBL199921 | — | — | 1 | 8.04 |
| CHEMBL372415 | — | — | 1 | 8.00 |
| CHEMBL427191 | — | — | 1 | 7.96 |
| CHEMBL425931 | — | — | 1 | 7.92 |
| CHEMBL201888 | — | — | 1 | 7.92 |
| CHEMBL201956 | — | — | 1 | 7.92 |
| CHEMBL201903 | — | — | 1 | 7.89 |
| CHEMBL382285 | — | — | 1 | 7.89 |
| CHEMBL383764 | — | — | 1 | 7.85 |
| CHEMBL372163 | — | — | 1 | 7.85 |
| CHEMBL202547 | — | — | 1 | 7.82 |
| CHEMBL202825 | — | — | 1 | 7.77 |
| CHEMBL201044 | — | — | 1 | 7.75 |
| CHEMBL369994 | — | — | 1 | 7.72 |
| CHEMBL202493 | — | — | 1 | 7.70 |
| CHEMBL201693 | — | — | 1 | 7.70 |
| CHEMBL382367 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381360 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL381360 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL381360 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL372343 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL202272 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL378816 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL201844 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL369933 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL371962 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL201817 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL408569 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL201043 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL370411 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL381736 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL199921 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL372350 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL372415 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL427191 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL201956 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL201888 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL425931 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL201903 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL382285 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL383764 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL372163 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL202547 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL202825 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL201044 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL369994 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL202493 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL201693 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL382367 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL201176 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL372162 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL202232 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL201729 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL202381 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL267033 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL383236 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL201904 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL370621 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL202334 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL382506 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL201891 | — | IC50 | = | 1800.0 | nM | 5.75 |