Assay Detail
Binding
CHEMBL864688
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Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cells
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.63 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194419 | — | — | 1 | 9.22 |
| CHEMBL208838 | — | — | 2 | 9.10 |
| CHEMBL211006 | — | — | 1 | 9.00 |
| CHEMBL425563 | — | — | 1 | 8.92 |
| CHEMBL377828 | — | — | 1 | 8.85 |
| CHEMBL208648 | — | — | 1 | 8.70 |
| CHEMBL377855 | — | — | 1 | 8.66 |
| CHEMBL425602 | — | — | 1 | 8.26 |
| CHEMBL378300 | — | — | 1 | 8.24 |
| CHEMBL378061 | — | — | 1 | 8.10 |
| CHEMBL377968 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194419 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL208838 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL211006 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL208838 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL425563 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL377828 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL208648 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL377855 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL425602 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL378300 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL378061 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL377968 | — | IC50 | = | 25.0 | nM | 7.60 |