Assay Detail

CHEMBL864723

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Functional

Cytotoxicity against rat PC12 cell line by [3H] thymidine incorporation assay

ChEMBL ↗

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Target

PC-12 (CHEMBL612556) ↗

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Primary target PC-12

CHEMBL612556

Anchored from Assay target.

Protein identity PC-12

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Cell Type	PC-12
Confidence	1 — Organism
Curated By	Intermediate

Target

PC-12 (CHEMBL612556) ↗

Type	CELL-LINE
Organism	Rattus norvegicus

Publication

Neurotrophic peptide aldehydes: solid phase synthesis of fellutamide B and a simplified analog.

Schneekloth JS, Sanders JL, Hines J, Crews CM.
Bioorg Med Chem Lett (2006) 16 : 3855 -3858
PubMed 16697191 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.57	8.78

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL209331	—	—	1	8.78
CHEMBL265252	FELLUTAMIDE B	—	1	6.36

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL209331	—	IC50	=	1.67	nM	8.78
CHEMBL265252	FELLUTAMIDE B	IC50	=	437.0	nM	6.36