Assay Detail
Functional
CHEMBL864733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against N-type calcium channel by calcium influx into IMR32 cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-dependent N-type calcium channel subunit alpha-1B (CHEMBL4478) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.48 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201566 | — | — | 1 | 6.17 |
| CHEMBL369934 | — | — | 1 | 6.10 |
| CHEMBL201984 | — | — | 1 | 6.08 |
| CHEMBL203041 | — | — | 1 | 6.05 |
| CHEMBL201860 | — | — | 1 | 6.00 |
| CHEMBL382072 | — | — | 1 | 6.00 |
| CHEMBL201258 | — | — | 1 | 5.96 |
| CHEMBL201306 | — | — | 1 | 5.89 |
| CHEMBL382528 | — | — | 1 | 5.82 |
| CHEMBL452076 | CILNIDIPINE | 3.0 | 1 | 5.80 |
| CHEMBL370409 | — | — | 1 | 5.77 |
| CHEMBL201057 | — | — | 1 | 5.77 |
| CHEMBL202374 | — | — | 1 | 5.75 |
| CHEMBL202464 | — | — | 1 | 5.70 |
| CHEMBL382236 | — | — | 1 | 5.54 |
| CHEMBL508181 | — | — | 1 | 5.46 |
| CHEMBL372748 | — | — | 1 | 5.41 |
| CHEMBL201599 | — | — | 1 | 5.35 |
| CHEMBL201257 | — | — | 1 | 5.34 |
| CHEMBL202459 | — | — | 1 | 5.21 |
| CHEMBL380499 | — | — | 1 | 5.00 |
| CHEMBL382629 | — | — | 1 | 4.96 |
| CHEMBL382450 | — | — | 1 | 4.68 |
| CHEMBL203470 | — | — | 1 | 4.62 |
| CHEMBL202605 | — | — | 1 | 4.55 |
| CHEMBL201401 | — | — | 1 | 4.43 |
| CHEMBL204486 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201566 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL369934 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL201984 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL203041 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL201860 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL382072 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL201258 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL201306 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL382528 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL452076 | CILNIDIPINE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL370409 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL201057 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL202374 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL202464 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL382236 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL508181 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL372748 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL201599 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL201257 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL202459 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL380499 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL382629 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL382450 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL203470 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL202605 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL201401 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL204486 | — | IC50 | = | 37000.0 | nM | 4.43 |