Assay Detail
Functional
CHEMBL864870
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Ratio of cytotoxicity against human Molt4 cells in normoxia to hypoxia after 48 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and hypoxic-cytotoxic activity of some 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.29 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.46 |
| CHEMBL209539 | — | — | 1 | 5.43 |
| CHEMBL380033 | — | — | 1 | 5.20 |
| CHEMBL211782 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL209539 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL380033 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL211782 | — | IC50 | = | 8670.0 | nM | 5.06 |