Assay Detail
Binding
CHEMBL864943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.82 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212041 | — | — | 1 | 7.09 |
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | 6.54 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212041 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL135191 | TIFENAZOXIDE | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 194000.0 | nM | - |