Assay Detail
Functional
CHEMBL865068
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Antagonist activity against bradykinin B2 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Bradykinin antagonists modified with dipeptide mimetic beta-turn inducers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.58 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028850 | ICATIBANT | 4.0 | 1 | 9.55 |
| CHEMBL267822 | — | — | 1 | 5.60 |
| CHEMBL218749 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028850 | ICATIBANT | Kd | = | 0.2818 | nM | 9.55 |
| CHEMBL267822 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL218749 | — | Kd | > | 10000.0 | nM | - |