Assay Detail
Binding
CHEMBL865082
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Inhibition of IKK beta
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.19 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311108 | — | — | 1 | 6.01 |
| CHEMBL207028 | — | — | 1 | 5.96 |
| CHEMBL193093 | — | — | 1 | 5.89 |
| CHEMBL207238 | — | — | 1 | 5.85 |
| CHEMBL383723 | — | — | 1 | 5.80 |
| CHEMBL382565 | — | — | 1 | 5.72 |
| CHEMBL377085 | — | — | 1 | 5.66 |
| CHEMBL207250 | — | — | 1 | 5.60 |
| CHEMBL207071 | — | — | 1 | 5.58 |
| CHEMBL443571 | — | — | 1 | 5.54 |
| CHEMBL381907 | — | — | 1 | 5.47 |
| CHEMBL207409 | — | — | 1 | 5.39 |
| CHEMBL383620 | — | — | 1 | 5.34 |
| CHEMBL379327 | — | — | 1 | 5.33 |
| CHEMBL207664 | — | — | 1 | 5.30 |
| CHEMBL207113 | — | — | 1 | 5.25 |
| CHEMBL207619 | — | — | 1 | 5.20 |
| CHEMBL383482 | — | — | 1 | 5.20 |
| CHEMBL444884 | — | — | 1 | 5.18 |
| CHEMBL207404 | — | — | 1 | 5.18 |
| CHEMBL207012 | — | — | 1 | 5.13 |
| CHEMBL377928 | — | — | 1 | 5.10 |
| CHEMBL206896 | — | — | 1 | 5.09 |
| CHEMBL206956 | — | — | 1 | 5.02 |
| CHEMBL207173 | — | — | 1 | 4.99 |
| CHEMBL206985 | — | — | 1 | 4.97 |
| CHEMBL207987 | — | — | 1 | 4.96 |
| CHEMBL206961 | — | — | 1 | 4.90 |
| CHEMBL382993 | — | — | 1 | 4.90 |
| CHEMBL211002 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311108 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL207028 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL193093 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL207238 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL383723 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL382565 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL377085 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL207250 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL207071 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL443571 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL381907 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL207409 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL383620 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL379327 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL207664 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL207113 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL207619 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL383482 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL444884 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL207404 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL207012 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL377928 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL206896 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL206956 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL207173 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL206985 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL207987 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL206961 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL382993 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL211002 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL207114 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL380073 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL207034 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL207940 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL540202 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL208516 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL207204 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL206683 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL208331 | — | IC50 | = | 35700.0 | nM | 4.45 |
| CHEMBL207297 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL207205 | — | IC50 | > | 27500.0 | nM | - |
| CHEMBL382421 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL207663 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL381932 | — | IC50 | > | 23500.0 | nM | - |
| CHEMBL207002 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL207609 | — | IC50 | > | 32500.0 | nM | - |
| CHEMBL383061 | — | IC50 | > | 39500.0 | nM | - |
| CHEMBL381518 | — | IC50 | > | 15500.0 | nM | - |
| CHEMBL382765 | — | IC50 | > | 49000.0 | nM | - |
| CHEMBL206734 | — | IC50 | > | 35000.0 | nM | - |