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Assay Detail

CHEMBL865201

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MAO-A activity
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Amine oxidase [flavin-containing] A (CHEMBL1951)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins.
Santana L, Uriarte E, González-Díaz H, Zagotto G, Soto-Otero R, Méndez-Alvarez E.
J Med Chem (2006) 49 : 1149 -1156
PubMed 16451079 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.01 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL372943 1 7.40
CHEMBL382645 1 5.60
CHEMBL201250 1 5.19
CHEMBL201777 1 5.14
CHEMBL201199 1 4.95
CHEMBL424673 1 4.92
CHEMBL202017 1 4.91
CHEMBL202218 1 4.67
CHEMBL372346 1 4.66
CHEMBL202018 1 4.37
CHEMBL202112 1 4.18
CHEMBL416 METHOXSALEN 4.0 1 4.07
CHEMBL202093 1 -
CHEMBL383284 1 -
CHEMBL201074 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL372943 IC50 = 40.0 nM 7.40
CHEMBL382645 IC50 = 2510.0 nM 5.60
CHEMBL201250 IC50 = 6430.0 nM 5.19
CHEMBL201777 IC50 = 7240.0 nM 5.14
CHEMBL201199 IC50 = 11130.0 nM 4.95
CHEMBL424673 IC50 = 11900.0 nM 4.92
CHEMBL202017 IC50 = 12350.0 nM 4.91
CHEMBL202218 IC50 = 21410.0 nM 4.67
CHEMBL372346 IC50 = 21740.0 nM 4.66
CHEMBL202018 IC50 = 43020.0 nM 4.37
CHEMBL202112 IC50 = 65250.0 nM 4.18
CHEMBL416 METHOXSALEN IC50 = 85110.0 nM 4.07
CHEMBL202093 IC50 > 200000.0 nM -
CHEMBL383284 IC50 > 200000.0 nM -
CHEMBL201074 IC50 > 200000.0 nM -