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Assay Detail

CHEMBL865337

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against HCT8 colon carcinoma cell
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-8
Confidence 1 — Organism
Curated By Intermediate

Target

HCT-8 (CHEMBL613510)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and antitumor activity of simplified ecteinascidin-saframycin analogs.
Liu ZZ, Wang Y, Tang YF, Chen SZ, Chen XG, Li HY.
Bioorg Med Chem Lett (2006) 16 : 1282 -1285
PubMed 16338237 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 6.03 7.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2304209 1 7.43
CHEMBL206343 1 7.00
CHEMBL2304213 1 6.62
CHEMBL380725 1 6.52
CHEMBL204013 1 6.51
CHEMBL2304211 1 6.47
CHEMBL190740 1 6.36
CHEMBL2304218 1 6.30
CHEMBL2304208 1 6.21
CHEMBL2304216 1 6.16
CHEMBL2304206 1 6.08
CHEMBL206549 1 5.93
CHEMBL2304220 1 5.91
CHEMBL2304212 1 5.89
CHEMBL203872 1 5.87
CHEMBL2304214 1 5.86
CHEMBL381694 1 5.85
CHEMBL379232 1 5.81
CHEMBL2304210 1 5.80
CHEMBL2304219 1 5.76
CHEMBL2304207 1 5.75
CHEMBL203906 1 5.73
CHEMBL381500 1 5.67
CHEMBL2304215 1 5.57
CHEMBL203595 1 5.48
CHEMBL203078 1 5.46
CHEMBL2304217 1 5.45
CHEMBL382866 1 5.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2304209 IC50 = 37.0 nM 7.43
CHEMBL206343 IC50 = 100.0 nM 7.00
CHEMBL2304213 IC50 = 240.0 nM 6.62
CHEMBL380725 IC50 = 300.0 nM 6.52
CHEMBL204013 IC50 = 310.0 nM 6.51
CHEMBL2304211 IC50 = 340.0 nM 6.47
CHEMBL190740 IC50 = 440.0 nM 6.36
CHEMBL2304218 IC50 = 500.0 nM 6.30
CHEMBL2304208 IC50 = 620.0 nM 6.21
CHEMBL2304216 IC50 = 690.0 nM 6.16
CHEMBL2304206 IC50 = 830.0 nM 6.08
CHEMBL206549 IC50 = 1170.0 nM 5.93
CHEMBL2304220 IC50 = 1230.0 nM 5.91
CHEMBL2304212 IC50 = 1280.0 nM 5.89
CHEMBL203872 IC50 = 1350.0 nM 5.87
CHEMBL2304214 IC50 = 1380.0 nM 5.86
CHEMBL381694 IC50 = 1420.0 nM 5.85
CHEMBL379232 IC50 = 1540.0 nM 5.81
CHEMBL2304210 IC50 = 1600.0 nM 5.80
CHEMBL2304219 IC50 = 1720.0 nM 5.76
CHEMBL2304207 IC50 = 1780.0 nM 5.75
CHEMBL203906 IC50 = 1850.0 nM 5.73
CHEMBL381500 IC50 = 2140.0 nM 5.67
CHEMBL2304215 IC50 = 2710.0 nM 5.57
CHEMBL203595 IC50 = 3280.0 nM 5.48
CHEMBL203078 IC50 = 3480.0 nM 5.46
CHEMBL2304217 IC50 = 3560.0 nM 5.45
CHEMBL382866 IC50 = 5150.0 nM 5.29