Assay Detail
Binding
CHEMBL865343
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Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
DNA topoisomerase 4 subunit A (CHEMBL4088) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.12 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203557 | — | — | 1 | 6.30 |
| CHEMBL205110 | — | — | 1 | 6.16 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 6.10 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.00 |
| CHEMBL203491 | — | — | 1 | 5.96 |
| CHEMBL382028 | — | — | 1 | 5.66 |
| CHEMBL204904 | — | — | 1 | 5.62 |
| CHEMBL380649 | — | — | 1 | 5.50 |
| CHEMBL425234 | — | — | 1 | 5.48 |
| CHEMBL203979 | — | — | 1 | 5.48 |
| CHEMBL204762 | — | — | 1 | 5.48 |
| CHEMBL379022 | — | — | 1 | 5.46 |
| CHEMBL204544 | — | — | 1 | 5.44 |
| CHEMBL202753 | — | — | 1 | 5.44 |
| CHEMBL204911 | — | — | 1 | 5.32 |
| CHEMBL380533 | — | — | 1 | 5.30 |
| CHEMBL381257 | — | — | 1 | 5.20 |
| CHEMBL204749 | — | — | 1 | 5.10 |
| CHEMBL206622 | — | — | 1 | 5.07 |
| CHEMBL203851 | — | — | 1 | 5.00 |
| CHEMBL203935 | — | — | 1 | 5.00 |
| CHEMBL204230 | — | — | 1 | 4.92 |
| CHEMBL378608 | — | — | 1 | 4.85 |
| CHEMBL206553 | — | — | 1 | 4.80 |
| CHEMBL381833 | — | — | 1 | 4.80 |
| CHEMBL204899 | — | — | 1 | 4.75 |
| CHEMBL382247 | — | — | 1 | 4.72 |
| CHEMBL206156 | — | — | 1 | 4.68 |
| CHEMBL382172 | — | — | 1 | 4.64 |
| CHEMBL202813 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203557 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL205110 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL203491 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL382028 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL204904 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL380649 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL425234 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL203979 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL204762 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL379022 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL204544 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL202753 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL204911 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL380533 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL381257 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL204749 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL206622 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL203935 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL203851 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL204230 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL378608 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL206553 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL381833 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL204899 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL382247 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL206156 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL382172 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL437129 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL202813 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL378604 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL425233 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL442792 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL383328 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL204346 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL202633 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL383001 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL204042 | — | IC50 | > | 38000.0 | nM | - |
| CHEMBL204320 | — | IC50 | > | 40000.0 | nM | - |