Assay Detail
Binding
CHEMBL865552
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Inhibition of human IMPDH2
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.91 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 7.96 |
| CHEMBL208921 | — | — | 1 | 7.89 |
| CHEMBL428633 | — | — | 1 | 7.70 |
| CHEMBL209069 | — | — | 1 | 7.64 |
| CHEMBL380059 | — | — | 1 | 7.62 |
| CHEMBL212620 | — | — | 1 | 7.17 |
| CHEMBL211023 | — | — | 1 | 7.07 |
| CHEMBL380155 | — | — | 1 | 7.03 |
| CHEMBL210910 | — | — | 1 | 7.02 |
| CHEMBL210909 | — | — | 1 | 6.88 |
| CHEMBL427225 | — | — | 1 | 6.78 |
| CHEMBL378089 | — | — | 1 | 6.61 |
| CHEMBL209723 | — | — | 1 | 6.59 |
| CHEMBL378113 | — | — | 1 | 6.56 |
| CHEMBL208748 | — | — | 1 | 6.54 |
| CHEMBL212170 | — | — | 1 | 6.30 |
| CHEMBL384908 | — | — | 1 | 6.30 |
| CHEMBL212199 | — | — | 1 | 6.30 |
| CHEMBL379098 | — | — | 1 | 6.13 |
| CHEMBL210515 | — | — | 1 | 6.11 |
| CHEMBL210957 | — | — | 1 | - |
| CHEMBL377836 | — | — | 1 | - |
| CHEMBL211273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL208921 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL428633 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL209069 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL380059 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL212620 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL211023 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL380155 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL210910 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL210909 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL427225 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL378089 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL209723 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL378113 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL208748 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL212170 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL384908 | — | IC50 | = | 506.0 | nM | 6.30 |
| CHEMBL212199 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL379098 | — | IC50 | = | 749.0 | nM | 6.13 |
| CHEMBL210515 | — | IC50 | = | 785.0 | nM | 6.11 |
| CHEMBL210957 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL377836 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL211273 | — | IC50 | > | 1000.0 | nM | - |