Assay Detail
Toxicity
CHEMBL865567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.89 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191054 | — | — | 1 | 5.60 |
| CHEMBL206845 | — | — | 1 | 4.68 |
| CHEMBL203230 | — | — | 1 | 4.40 |
| CHEMBL203013 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191054 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL206845 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL203230 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL203013 | — | IC50 | > | 30000.0 | nM | - |